Available methylation tests

Impaired methylation diagnostic markers
  • Irregular methionine, cysteine, S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), homocysteine and cystathionine plasma levels
  • Homocysteine plasma level above normal range
  • Histamine plasma level above normal range
  • Histamine urine level above normal range
  • High or low basophil blood count level
  • Mutation of either or both of the C677T and A1298C variants of the MTHFR gene

Below are the possible outcomes of an MTHFR gene test result:
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MTHFR C677C = normal MTHFR gene - normal methylation function
MTHFR C677T = heterozygous mutation (one mutation) - 40% loss of methylation function
MTHFR T677T = homozygous mutation (two mutations) - 70% loss of methylation function
 
MTHFR A1298A = normal MTHFR gene - normal methylation function
MTHFR A1298C = heterozygous mutation (one mutation) - 20% loss of methylation function
MTHFR C1298C = homozygous mutation (two mutations) - 40% loss of methylation function
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MTHFR C677T + MTHFR A1298C = a compound heterozygous mutation - 50% loss of methylation function
Please note: mindovermetal are unable to provide the basophil blood count test. This test will need to be requested at your doctors surgery or carried out via another external service. 
​​Main diagnostic tests
  • Methylation profile test​​ (Biolab appointments only)
  • Homocysteine plasma test (for the homocysteine plasma test please click here)
  • Histamine plasma test 
  • Histamine urine test
  • Basophil blood count test
  • MTHFR gene mutation (C677T and A1298C) saliva test​
Please note: You do not necessarily need to undergo all of the tests to diagnose whether or not you have any methylation issues/impairment. The methylation profile test analyses specific amino acids which are key substances involved in methylation, this test is only available to undergo at Biolab's location in London though. The MTHFR gene saliva test analyses potential mutations in the C677T and A1298C variants of the gene. These gene variants play a vital role in methylation. An increase of histamine and homocysteine can occur from methylation problems. Sometimes both histamine and homocysteine can actually be within range though when someone is undermethylated, being undermethylated does not always mean that you will have high histamine and homocysteine levels but the risk is greater. 
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