Histadelia - undermethylation (high blood histamine)
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What is histadelia?
Histadelia, also known as undermethylation is a genetic metabolic/biochemical issue in which too much histamine is produced by way of too few methyl groups which are responsible for breaking down excess histamine. The result of this is elevated blood histamine levels which has an effect on mental and physical health. Not only is histamine involved in inflammatory responses but it also acts as a neurotransmitter which is why imbalances can affect brain chemistry. |
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What are the symptoms and conditions associated with histadelia?
People with high histamine levels do not often appear to be depressed and this issue can be associated with motivated and driven people who are successful in their careers and work life but hide their true thoughts and feelings. People with histadelia are often creative people who have good ideas but suffer with a feeling of constant mild inner tension and have changes of belief about current projects and ventures.
With this biochemical issue also comes the feeling of the mind racing and the inability to switch off and possible chronic depression. Being under-methylated is associated with low serotonin levels and many people with histadelia have obsessive-compulsive tendencies, other features of this biochemical issue include frequent headaches, perfectionism and competitiveness.
Histamine excess can manifest as asthma, allergic skin disorders, vasomotor rhinitis, excess stomach acid production, heavy production of saliva and tears and thin nasal bronchial secretion.
Histamine also has an effect on adrenaline so therefore fatigue can be common in people with histadelia. Using drugs and alcohol to eliminate blood histamine and provide a lift is another common factor in high histamine individuals.
Below is a list of the signs, symptoms and disorders which can be associated with histadelia:
People with high histamine levels do not often appear to be depressed and this issue can be associated with motivated and driven people who are successful in their careers and work life but hide their true thoughts and feelings. People with histadelia are often creative people who have good ideas but suffer with a feeling of constant mild inner tension and have changes of belief about current projects and ventures.
With this biochemical issue also comes the feeling of the mind racing and the inability to switch off and possible chronic depression. Being under-methylated is associated with low serotonin levels and many people with histadelia have obsessive-compulsive tendencies, other features of this biochemical issue include frequent headaches, perfectionism and competitiveness.
Histamine excess can manifest as asthma, allergic skin disorders, vasomotor rhinitis, excess stomach acid production, heavy production of saliva and tears and thin nasal bronchial secretion.
Histamine also has an effect on adrenaline so therefore fatigue can be common in people with histadelia. Using drugs and alcohol to eliminate blood histamine and provide a lift is another common factor in high histamine individuals.
Below is a list of the signs, symptoms and disorders which can be associated with histadelia:
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Histadelia testing
Testing for histadelia involves a histamine plasma test or a histamine urine test. Testing histamine levels via blood is the preferable option but both tests can done to give more of a definite diagnosis or if one testing method proves to be negative then the other can be done just to make sure that there is not an irregular histamine level. If the histamine plasma or urine test is a positive result then a basophil blood test will be required in order to make the histadelia diagnosis affirmative. The basophil blood test is important because high histamine plasma or urine levels can sometimes be due to histamine intolerance rather than histadelia itself. Another important test for histadelia is the MTHFR gene test which will analyse an undermethylation problem if there is one. If the methylation cycle is impaired then it affects the breakdown of histamine in the body resulting in increased histamine levels. For histadelia testing please click here for the available tests page.
Testing for histadelia involves a histamine plasma test or a histamine urine test. Testing histamine levels via blood is the preferable option but both tests can done to give more of a definite diagnosis or if one testing method proves to be negative then the other can be done just to make sure that there is not an irregular histamine level. If the histamine plasma or urine test is a positive result then a basophil blood test will be required in order to make the histadelia diagnosis affirmative. The basophil blood test is important because high histamine plasma or urine levels can sometimes be due to histamine intolerance rather than histadelia itself. Another important test for histadelia is the MTHFR gene test which will analyse an undermethylation problem if there is one. If the methylation cycle is impaired then it affects the breakdown of histamine in the body resulting in increased histamine levels. For histadelia testing please click here for the available tests page.
Histadelia treatment
Treatment for histadelia involves dietary changes, lifestyle changes and supplement use to correct certain biochemical imbalances and to lower histamine levels. If you undergo testing for histadelia and you test positive then you will receive the treatment programme attached in the results email. If you have any questions about your results then mindovermetal will answer them for you.
MTHFR Gene Mutations
MTHFR gene mutations cause metabolic problems relating to vitamin B9 (folate), it also affects other biochemical formations and synthesizes. MTHFR gene mutations are associated with a number of different mental and physical health problems. For more information on MTHFR gene mutations please click here.
MTHFR gene mutations cause metabolic problems relating to vitamin B9 (folate), it also affects other biochemical formations and synthesizes. MTHFR gene mutations are associated with a number of different mental and physical health problems. For more information on MTHFR gene mutations please click here.
