Pyroluria urine test UK and Europe
Order Guidelines/Laboratory Info
- Once you have paid for the test you will receive a confirmation email
- Testing laboratory - Biolab Medical Unit are based in the West End of London and they specialise in nutritional and environmental medicine offering a wide range of tests and a test referral service (for their website please click here)
- Test kit delivery - Test kits ordered before 3pm Monday to Friday will be sent out the same day. Test kits ordered after 3pm Monday to Thursday will be sent out the following day morning time. Test kits ordered after 3pm Friday and over the course of the weekend will not be sent out till Monday morning the following week
- Treatment programme - If you test positive for pyroluria then you will receive a treatment programme which is included in the price of the test. You will also receive practitioner support via email
- Sample collection/sending - The test kit is sent directly to you and the sample can be collected at home. The test kit comes with instructions on how to collect the sample and comes with the relevant packaging for you to send it back to the laboratory. Once the sample has been collected you need to post the kit back to Biolab. Normal postal charges will apply (large letter rates UK). It is advised to send the sample at the start of the week so that the laboratory receives it during the same working week. Please note: Although Biolab have stated on their website that the sample needs to reach the laboratory within 48 hours, the sample is fine in transit for a maximum of 5 days. This has been confirmed by Biolab and this will suit test orders from outside of the UK and any delayed samples in transit within the UK
- Zinc and vitamin B6 supplements - Vitamin B6 and zinc supplements can lower kryptopyrrole urine levels in as little as 2 - 3 weeks and can give an untrue reading of natural urine levels (pyroluria induced or normal). If you are currently taking vitamin B6 and zinc supplements then you have two options. Option 1 - You can stop taking these supplements and achieve a more accurate result but you would need to wait at least 5 weeks before collecting the sample. You may experience mental and physical symptoms if you do stop supplement use so please bear this in mind. Option 2 - You can collect the sample whilst taking zinc and vitamin B6 but you may not get a true reading of the level of kryptopyrroles that your body produces. Kryptopyrrole urine levels can still show up above the reference range whilst taking zinc and vitamin B6 and positive results can be produced but there is still the potential for untrue readings. Please note: Biolab have stated on their website that it is not necessary to stop any form of supplements before collecting the sample. This is because it would take a considerable amount of time (at least 5 weeks or so) for any kind of response to happen in kryptopyrrole urine levels and there is the risk of experiencing mental and physical health symptoms (this is why mindovermetal have stated this with regards to option one). Mindovermetal have had previous patients test positive for pyroluria but then test negative 3 - 4 weeks later after starting a zinc and vitamin B6 supplement regime, this is why mindovermetal want people to achieve the most accurate result possible
- Freezing - Some laboratories and testing services for pyroluria advise that the sample must be sent frozen until it reaches the lab, this is not the case with Biolab - ''There’s no harm in freezing krypto-pyrrole samples if a patient prefers to do that, but we have looked at this closely and samples left on the lab bench at ambient temperature do not decrease their kryptopyrrole value over a period of 5-10 days. Sensitivity to light and adding ascorbic acid to the sample (covered if patients use our test kits) are more important in terms of kryptopyrrole preservation. Some people are so concerned about this they even send the samples on dry-ice to us from outside of the UK, but if we leave the samples at ambient temperature and re-test a week later the results are the same. Some other labs measure slightly different compounds (HPL etc) to diagnose pyroluria and it is possible that these compounds are more temperature sensitive.'' If you would still like to send the sample frozen and make your own personal arrangements then this is fine
- Please note: You can only order this test within Europe
- Refunds - Refunds are only possible if the test kit is unused and no samples have been sent to Biolab. If a refund is required then please email - orders@mindovermetal.co.uk, someone will then be in contact to process your refund
- Results - The test result is sent directly to you from mindovermetal Ltd and not from Biolab. The result is sent to the email that you provide when you place your order. Test results will come with an email from mindovermetal Ltd summarising your result reading. The test result is simple to understand and shows if you are above, below or within certain reference ranges. The turnaround time for results once the sample has reached the laboratory is 5 - 7 working days. Please make a note of the date you send the sample and if you do not receive your results within the time frame then please email orders@mindovermetal.co.uk and someone will be in contact
- Kryptopyrrole or HPL/HPU - There is some confusion about wherever or not Kryptopyrroles or HPL/HPU should be measured to diagnose pyroluria. More info about this can be found in the downloadable info document below. If you have any questions then please contact mindovermetal
- More info - You can find more info about the test by clicking here and you can also download this info document from Biolab:
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Description from Biolab
Measurement of urine kryptopyrroles may be indicated in subjects with central nervous system problems where the clinician suspects a deficiency of trace elements or vitamins. “Pyroluria” (the syndrome that accompanies urinary excretion of kryptopyrroles) is a disorder in which haemoglobin synthesis is upregulated as a consequence of deficiencies of these micronutrients; unusual by-products of haemoglobin intermediates subsequently appear in the urine. In this respect it is similar to the various porphyria syndromes, especially the acquired porphyrinurias. Pyroluria is, however, especially associated with psychiatric symptoms such as schizophrenia. The term “Kryptopyrrole” was coined to describe substances derived from haemoglobin precursors identified in the urine of some psychiatric patients.
Measurement of urine kryptopyrroles may be indicated in subjects with central nervous system problems where the clinician suspects a deficiency of trace elements or vitamins. “Pyroluria” (the syndrome that accompanies urinary excretion of kryptopyrroles) is a disorder in which haemoglobin synthesis is upregulated as a consequence of deficiencies of these micronutrients; unusual by-products of haemoglobin intermediates subsequently appear in the urine. In this respect it is similar to the various porphyria syndromes, especially the acquired porphyrinurias. Pyroluria is, however, especially associated with psychiatric symptoms such as schizophrenia. The term “Kryptopyrrole” was coined to describe substances derived from haemoglobin precursors identified in the urine of some psychiatric patients.
